師資
董哲,南方科技大學(xué)化學(xué)系副教授(研究員),博士生導(dǎo)師。2012年本科畢業(yè)北京大學(xué), 師從余志祥教授。2012年至2016年,在德州大學(xué)奧斯汀分校董廣彬教授課題組攻讀博士學(xué)位。2016年隨著課題組一起轉(zhuǎn)入芝加哥大學(xué),并于2018年獲得美國(guó)芝加哥大學(xué)博士學(xué)位。同年加入普林斯頓大學(xué)2021年化學(xué)諾貝爾獎(jiǎng)得主有機(jī)化學(xué)家David Macmillan教授課題組從事博士后工作研究。2020年入選海外高層次人才計(jì)劃青年項(xiàng)目,2021年加入南方科技大學(xué)化學(xué)系。2022年獲批科技部重點(diǎn)研發(fā)專項(xiàng)課題負(fù)責(zé)人;參與孔雀團(tuán)隊(duì)和廣創(chuàng)團(tuán)隊(duì)。
主要研究方向?yàn)椋?/strong>
1.立體專一型的偶聯(lián)反應(yīng):純烷基手性季碳是有機(jī)合成中難點(diǎn),我們開發(fā)了一系列以手性環(huán)氧和手性醇為原料的手性季碳構(gòu)筑方法,高效高選擇性地將手性碳氧鍵轉(zhuǎn)化為了手性碳碳鍵。首次發(fā)展了立體專一型的同面取代反應(yīng),豐富了取代反應(yīng)的類型。
2. 碳正離子與碳負(fù)離子的直接取代反應(yīng):發(fā)展了一系列調(diào)控碳正離子活性的新方法來高效構(gòu)筑季碳
3. 新型生物標(biāo)記探針的設(shè)計(jì)合成:開發(fā)適用于生物體系近程標(biāo)記反應(yīng)的新型多功能探針
榮譽(yù)獎(jiǎng)勵(lì):
2015年獲得國(guó)家優(yōu)秀自費(fèi)留學(xué)生獎(jiǎng)學(xué)金;
2017年入選Reaxy-PHD獎(jiǎng)最終名單
2018年獲得芝加哥大學(xué)優(yōu)秀博士論文獎(jiǎng);
2020年入選海外高層次人才計(jì)劃青年項(xiàng)目
近年資助:
2021-2024,海外高層次人才計(jì)劃青年項(xiàng)目
代表性論文:
2025
24.Synthesis of chiral germanium center enabled by poly-deborylative alkylation and desymmetrization.
Ke Wang, Xin-Yuan Liu & Zhe Dong*,Nature Communications,2025,https://doi.org/10.1038/s41467-025-60397-x
2024
23.Accurate triplet energies prediction method based on the hot-bandmodel.
Wenbin Huang and Zhe Dong*,Chem , 2024,doi.org/10.1016/j.chempr.2024.10.014.
22.Aqueous alkaline phosphate facilitates the nonexchangeable deuteration of peptides and proteins.
Tingting Zhang, Zhixiong Jin, Heng Zhao, Can Lai,Zheyi Liu, Pan Luo,Zhe Dong and Fangjun Wang*.RSC Adv., 2024, 14, 8075,
doi: 10.1039/d3ra08636d
21.Copper-Catalyzed Asymmetric Three-Component Radical 1,2-Carboamination of Acrylamides with Arylamines: Access to Chiral α-Tertiary N-Arylamines.
Jia-Heng Fang?, Ji-Jun Chen?, Xuan-Yi Du?, Zhe Dong?, Run-Yan Tian, Chang-Jiang Yang, Fu-Li Wang,Cheng Luan, Zhong-Liang Li & Xin-Yuan Liu*,CCS Chem. 2024,doi: 10.31635/ccschem.024.202404389.
20.Probing the functional hotspots inside protein hydrophobic pockets by in situ photochemical trifluoromethylation and mass spectrometry.
Can Lai, Zhiyao Tang,Zheyi Liu, Pan Luo, Wenxiang Zhang,Tingting Zhang,Wenhao Zhang,Zhe Dong,*Xinyuan Liu, Xueming Yang and Fangjun Wang*,Chemical Science2024,doi:10.1039/d3sc05106d.
2023
19.Reversible C–H sampling for direct functional group translocation.
Ke Wang and Zhe Dong*Chem Catalysis2023,doi:10.1016/j.checat.2023.100856.
18.Enantioconvergent Cu-catalysed N-alkylation of aliphatic amines.
Ji-Jun Chen, Jia-Heng Fang, Xuan-Yi Du, Jia-Yong Zhang, Jun-Qian Bian, Fu-Li Wang, Cheng Luan, Wei-Long Liu, Ji-Ren Liu, Xiao-Yang Dong, Zhong-Liang Li, Qiang-Shuai Gu, Zhe Dong & Xin-Yuan Liu* Nature 2023,doi.org/10.1038/s41586-023-05950-8
17.Dual-catalyst-enabled olefin 1,2-difunctionalization for a-chloroalkylboronic esters.
Zhe Dong* chem.2023, 9, 8–15,doi:10.1016/j.chempr.2022.12.009.
Prior to SUSTech
16. Metallaphotoredox-enabled deoxygenative arylation of alcohols.
Zhe Dong, David W.C. Macmillan* Nature 2021, doi: 10.1038/s41586-021-03920-6.
15. Compatibility Score for Rational Electrophile Selection in Pd/NBE Cooperative Catalysis.
Xiaotian Qi, Jianchun Wang, Zhe Dong, Guangbin Dong*, Peng Liu* Chem. 2020, 6, 2810.
14. A Mechanistic Analysis of Metallaphotoredox C–N Coupling: Photocatalysis Initiates and Perpetuates Ni(I)/Ni(III) Coupling Activity.
Nicholas A. Till, Lei Tian, Zhe Dong, Gregory Scholes, and David W. C. MacMillan* J. Am. Chem. Soc. 2020, 142, 15830.
13. Modular and Regioselective Synthesis of All-Carbon Tetrasubstituted Olefins Enabled by an Alkenyl Catellani Reaction.
Jianchun Wang, Zhe Dong, Cheng Yang, and Guangbin Dong* Nat. Chem. 2019, 11, 1106.
12. Sulfenamide-Enabled Ortho Thiolation of Aryl Iodides via Palladium/Norbornene Cooperative Catalysis.
Renhe Li, Yun Zhou, Ki-Young Yoon, Zhe Dong* and Guangbin Dong* Nat. Commun. 2019, 10, 3555.
11. Palladium/Norbornene-Catalyzed Indenone Synthesis from Simple Aryl Iodides: Concise Syntheses of Pauciflorol F and Acredinone A.
Feipeng, Liu; Zhe, Dong; Jianchun, Wang; Guangbin, Dong.* Angew. Chem., Int. Ed. 2019, 58, 2144.
10. Complementary Site-Selectivity in Arene Functionalization Enabled by Overcoming the “Ortho Constraint” in the Palladium/Norbornene Catalysis.
Jianchun Wang, Renhe Li, Zhe Dong, Peng Liu and Guangbin Dong* Nat. Chem. 2018, 10, 866.
9. Modular ipso/ortho Difunctionalization of Aryl Bromides via Palladium/Norbornene Cooperative Catalysis.
Zhe Dong, Gang Lu, Jianchun Wang, Peng Liu* and Guangbin Dong* J. Am. Chem. Soc. 2018, 140, 8551.
8. Transition metal catalyzed C-H bond alkylation using alkenes.
Zhe Dong, Zhi Ren, Samuel J. Thompson, Yan Xu and Guangbin Dong* Chem. Rev. 2017, 117, 9333.
7. New Directions in Pd/Norbornene-Catalyzed Activation of Arene C–H Bonds.
Zhe Dong.* Chem. 2016, 1, 520.
6. Reagent-Enabled Ortho Alkoxycarbonylation of Aryl Iodides via Palladium/Norbornene Catalysis
Jianchun, Wang; Lei, Zhang; Zhe Dong;* Guangbin, Dong.* Chem. 2016, 1, 581.
5. Ortho C?H Acylation of Aryl Iodides by Palladium/Norbornene Catalysis.
Zhe, Dong; Jianchun, Wang; Zhi, Ren; Guangbin, Dong.* Angew. Chem., Int. Ed. 2015, 54, 12664.
4. Simple Amine-Directed meta-Selective C?H Arylation via Pd/Norbornene Catalysis.
Zhe, Dong; Jianchun, Wang; Guangbin, Dong.* J. Am. Chem. Soc. 2015, 137, 5887.
3. Ortho vs Ipso: Site-Selective Pd and Norbornene-Catalyzed Arene C–H Amination Using Aryl Halides.
Zhe Dong and Guangbin Dong.* J. Am. Chem. Soc., 2013, 135, 18350.
2. Gold(I)-Catalyzed endo-Selective Intramolecular α-Alkenylation of β-Yne-Furans: Synthesis of Seven-Membered-Ring-Fused Furans and DFT Calculations.
Zhe Dong, Cheng-Hang Liu, Yi Wang, Mu Lin and Zhi-Xiang Yu.* Angew. Chem. Int. Ed. 2013, 52, 14157.
1. α,β-Divinyl Tetrahydropyrroles as Chiral Chain Diene Ligands in Rhodium(I)-Catalyzed Enantioselective Conjugated Additions.
Qian Li, Zhe Dong, and Zhi-Xiang Yu* Org. Lett., 2011, 13, 1122.
