師資
個(gè)人簡介
傅暘,博士,南方科技大學(xué)醫(yī)學(xué)院生物化學(xué)系正高級研究員/長聘副教授,博士生導(dǎo)師,國家海外高層次青年人才,深圳市孔雀人才?,F(xiàn)任南方科技大學(xué)生物安全平臺副主任、深圳市科創(chuàng)委新藥與疫苗專委委員。2013年獲南開大學(xué)生物化學(xué)與分子生物學(xué)博士學(xué)位、哈佛大學(xué)醫(yī)學(xué)院聯(lián)合培養(yǎng)微生物學(xué)博士(2008-2013)。師從世界著名微生物學(xué)家、美國科學(xué)院院士John Mekalanos教授。
2019年于南科大獨(dú)立建組以來,傅暘團(tuán)隊(duì)的科研工作方聚焦一個(gè)核心即細(xì)菌源性的大分子跨膜遞送系統(tǒng),著眼其系統(tǒng)激活及動(dòng)態(tài)作用機(jī)理、效應(yīng)蛋白作用機(jī)制、遺傳元件的功能解析、原核互作與真核互作等面向,深入研究理論基礎(chǔ)并橋接應(yīng)用轉(zhuǎn)化方向;同時(shí),課題組基于在病原微生物學(xué)的長期積淀也響應(yīng)國家與深圳市號召開展部分新冠與猴痘病毒等新發(fā)突發(fā)傳染病病原的應(yīng)急攻關(guān)研究。
我們鮮明研究特色是以革蘭氏陰性細(xì)菌VI型分泌系統(tǒng)(T6SS)、胞外注射器(eCIS)兩類典型的‘注射式分泌體統(tǒng)’為對象開展:1)精準(zhǔn)抗菌機(jī)制與機(jī)理;2)細(xì)胞水平蛋白質(zhì)精準(zhǔn)遞送;3)合成生物學(xué)應(yīng)用技術(shù)研究。目前傅暘團(tuán)隊(duì)累計(jì)發(fā)表研究論文39篇(南科大31篇),以通訊作者或第一作者身份發(fā)表,Cell Host & Microbe (3篇), Mol Cell, PNAS, Gut Microbes, Advanced Functional Materials, J Biol Chem(2篇), Microbiol Res (2篇),mLife等高水平研究論文21篇。論文總引超5700次。申請技術(shù)發(fā)明專利7項(xiàng),并已成功實(shí)現(xiàn)產(chǎn)業(yè)轉(zhuǎn)化300萬元。
本團(tuán)隊(duì)累計(jì)主持國家自然科學(xué)基金委面上項(xiàng)目和青年項(xiàng)目、中組部、廣東省、深圳市科創(chuàng)委基礎(chǔ)研發(fā)重點(diǎn)專項(xiàng)、深圳市科創(chuàng)委孔雀團(tuán)隊(duì)項(xiàng)目、深圳市抗疫應(yīng)急攻關(guān)重點(diǎn)專項(xiàng)、深圳市醫(yī)學(xué)科學(xué)院(SMART)等二十余項(xiàng)項(xiàng)目,科研經(jīng)費(fèi)充足。
學(xué)術(shù)任職
1、Bio-Protocol雜志編輯
2、Frontiers Cellular and Infection Microbiology??庉?
獲獎(jiǎng)榮譽(yù)
1、國家級人才頭銜
2、深圳市人才頭銜
3、Fogarty Global Health Fellowship
教育經(jīng)歷
1、2001.09-2005.06 江南大學(xué),生物工程學(xué)專業(yè)學(xué)士
2、2006.09-2013.06 南開大學(xué),生物化學(xué)與分子生物學(xué)專業(yè)博士
3、2009.09-2013.05 哈佛大學(xué),微生物學(xué)與免疫生物學(xué)專業(yè)聯(lián)培博士
工作經(jīng)歷:
1、2005.07-2006.08 南開大學(xué),技術(shù)員
2、2008.06-2009.01 哈佛大學(xué)公共衛(wèi)生學(xué)院,交換生
3、2013.07-2018.06 哈佛大學(xué)醫(yī)學(xué)院,博士后研究員
4、2018.07-2019.06 哈佛大學(xué)醫(yī)學(xué)院,助理研究員
5、2019.06-2020.12 南方科技大學(xué),助理教授/博士生導(dǎo)師
6、2021.01-至今 南方科技大學(xué),副教授/博士生導(dǎo)師
已發(fā)表論文:
* Contributed equally to the work and # for corresponding authors
Representative papers at SUSTech as a Corresponding author:
-
Liu M, Wang H, Wang Z, Wang H, Zhang K, Xue J, Liu R, Liu Y, Xia P, Wang H, Kan B, Li Y, Li S, Fu Y#. A Vibrio-specific T6SS effector reshapes microbial competition by disrupting Vibrio bioenergetics. Cell Host and Microbe. 2025; 33(7): 1146-1160. e8.
-
Liu RH*, Zhang K*, Feng QS, He SJ, Fan QY, Zhang X, Li W, Bao ZP, Lin WF, Fu Y#, Li Y#. Unveiling Acidophilic Secretin Nanopores for Ion Exclusion and Single-molecule Sensing. Advanced Functional Materials. 2025, in press.
-
Wang H, Liu Y, Wang Z, Xia P, Li Z, Liu M#, Fu Y#. Functional Insights into the Type VI Secretion System of Multi-drug Resistant Aeromonas hydrophila: A Key Factor in Competition and Pathogenesis. mLife. 2025; 4(4): 363-377.
-
Guo HH, Zhang Q, Wang Z, Zhang K#, Fu Y#. Structural insight into Vibrio cholerae EIIC Sugar Transporter Dimer Captured in a Substrate-Free Inward-facing State. Acta Biochimica et Biophysica Sinica. 2025; 57(x):1-8.
-
Feng Q, Dai, X, Wu, Q, Zhang L#, Yang L#, Fu Y#. C-di-GMP phosphodiesterase ProE interacts with quorum sensing protein PqsE to promote pyocyanin production in Pseudomonas aeruginosa. mSphere. 2025; e01026-24.
-
Xiang Q, Wu J, Zhou Y, Li L, Tian M, Li G#, Zhang Z#, Fu Y#. SARS-CoV-2 Membrane protein regulates the function of Spike by inhibiting its plasma membrane localization and enzymatic activity of Furin. Microbiol Res. 2024; 282:127659.
-
Feng Q, Zhou J, Zhang L, Fu Y#, Yang L#. Insights into the molecular basis of c-diGMP signalling in Pseudomonas aeruginosa. Crit Rev Microbiol. 2024; 50(1): 20-38.
-
Yu B*, Lu Q*, Li J*, Cheng X*, Hu H, Li Y, Che T, Hua Y, Jiang H, Zhang Y, Xian C, Yang T, Fu Y, Chen Y, Nan W, McCormick PJ, Xiong B, Duan J, Zeng B, Li Y#, Fu Y#, Zhang J#. Cryo-EM structure of human HCN3 channel and its regulation by cAMP. J Biol Chem. 2024; 300(6): 107288.
-
Zhang Y*, Wang D*, Xiang Q*, Hu X, Zhang Y, Wu L, Zhang Z, Wang Y, Zhao J, McCormick PJ, Fu J#, Fu Y#, Zhang J#, Jiang H#, Li J#. A potent neutralizing nanobodytargeting a unique epitope on the receptor-binding domain of SARS-CoV-2 spike protein. Virology. 2024; 589: 109925.
-
Liu M*, Wang H*, Liu Y, Tian M, Wang Z, Shu RD, Zhao MY, Chen WD, Wang H, Wang H, Fu Y#. The phospholipase effector Tle1(Vc) promotes Vibrio cholerae virulence by killing competitors and impacting gene expression. Gut Microbes. 2023; 15(1): 2241204.
-
Liu M*, Zhao MY*, Wang H, Wang ZH, Wang Z, Liu Y, Li YP, Dong T, Fu Y#. Pesticin-Like Effector VgrG3(cp) Targeting Peptidoglycan Delivered by the Type VI Secretion System Contributes to Vibrio cholerae Interbacterial Competition. Microbiol Spectr. 2023; 11(1): e0426722.
-
Zhang K*, Peng T*, Tao X*, Tian M*, Li Y, Wang Z, Ma S, Hu S, Pan X, Xue J, Luo J, Wu Q, Fu Y#, Li S#. Structural insights into caspase ADPR deacylization catalyzed by a bacterial effector and host calmodulin. Mol Cell. 2022; 82(24): 4712-4726. e4717.
-
Xiang Q, Li L, Wu J, Tian M, Fu Y#. Application of pseudovirus system in the development of vaccine, antiviral-drugs, and neutralizing antibodies. Microbiol Res. 2022; 258: 126993.
-
Song X*, Li J*, Tian M*, Zhu H, Hu X, Zhang Y, Cao Y, Ye H, McCormick PJ, Zeng B, Fu Y#, Duan J#, Zhang J#. Cryo-EM structure of mouse TRPML2 in lipid nanodiscs. J Biol Chem. 2022; 298(2): 10148.
-
Chen Y*, Wang S*, Huang J*, Fu Y, Wen J, Zhou C, Fu Y#, Liu L#. Application of extracorporeal carbon dioxide removal combined with continuous blood purification therapy in ARDS with hypercapnia in patients with critical COVID-19. Clin Hemorheol Microcirc. 2021; 78(2): 199-207.
-
Cai Q*, Huang D*, Ou P*, Yu H, Zhu Z, Xia Z, Su Y, Ma Z, Zhang Y, Li Z, He Q, Liu L#, Fu Y#, Chen J#. COVID-19 in a designated infectious diseases hospital outside Hubei Province, China. Allergy. 2020; 75(7): 1742-1752.
Before joining SUSTech
-
Fu Y*, Ho BT*, Mekalanos JJ#. Tracking Vibrio cholerae Cell-Cell Interactions during Infection Reveals Bacterial Population Dynamics within Intestinal Microenvironments. Cell Host and Microbe. 2018; 23(2): 274-281 e272.
-
Ho BT*, Fu Y*, Dong TG, Mekalanos JJ#. Vibrio cholerae type 6 secretion system effector trafficking in target bacterial cells. Proc Natl Acad Sci USA. 2017; 114(35): 9427-9432.
-
Fu Y, Waldor MK, Mekalanos JJ#. Tn-Seq analysis of Vibrio cholerae intestinal colonization reveals a role for T6SS-mediated antibacterial activity in the host. Cell Host and Microbe. 2013; 14(6): 652-663.
