師資
個(gè)人簡(jiǎn)介：
南方科技大學(xué)醫(yī)學(xué)院藥理學(xué)系副教授，研究員（正高級(jí)）。2006年德國(guó)馬克斯普朗克分子遺傳所獲得功能基因組學(xué)博士學(xué)位，07年于同所建立獨(dú)立實(shí)驗(yàn)室，擔(dān)任青年科學(xué)家小組組長(zhǎng)（等同于德國(guó)一流高校副教授）。2009年起任德國(guó)馬科斯德?tīng)柌紖慰藝?guó)家分子醫(yī)學(xué)中心/柏林系統(tǒng)生物醫(yī)學(xué)研究所高級(jí)研究員。2016年8月加入南方科技大學(xué)。
長(zhǎng)期從事功能基因組/系統(tǒng)生物學(xué)、藥理學(xué)領(lǐng)域的研究，在新藥研發(fā)方面也富有經(jīng)驗(yàn)。聚焦功能基因組學(xué)領(lǐng)域的研究，曾建立基于細(xì)胞芯片技術(shù)的包括蛋白質(zhì)亞細(xì)胞定位，誘導(dǎo)細(xì)胞凋亡，蛋白質(zhì)－蛋白質(zhì)交互作用等多項(xiàng)高通量基因功能研究平臺(tái)。近年來(lái)，致力于發(fā)展適用于基因調(diào)控研究和藥理學(xué)的系統(tǒng)生物學(xué)手段，特別是結(jié)合高通量測(cè)序、單細(xì)胞和空間多組學(xué)技術(shù)、表觀(guān)基因組學(xué)、CRISPR基因編輯篩選等前沿技術(shù)。并整合蛋白組/代謝組學(xué)等多組學(xué)手段，詮釋與發(fā)育進(jìn)程、腫瘤病理和藥物治療機(jī)制相關(guān)的核心基因調(diào)控網(wǎng)絡(luò)。
近五年以通訊（共同通訊）作者在 Cell，Developmental cell, Nature Communication, Pharmacological research, Oncogene, Genomics Proteomics and Bioinformatics,iScience 期刊發(fā)表研究論文 7 篇。入職南科大后發(fā)表研究論文共計(jì)>23 篇。
總引用超2900次，近5年引用數(shù)超1400次。H-指數(shù)25，i10-指數(shù)34 （google scholar，2025/07）。已申請(qǐng)抗腫瘤、抗新冠的天然化合物，單細(xì)胞技術(shù)等發(fā)明專(zhuān)利8項(xiàng)，已授權(quán)4項(xiàng)。已承擔(dān)國(guó)家和省市項(xiàng)目6項(xiàng)，總科研經(jīng)費(fèi)超714萬(wàn)元。
深圳市鵬城孔雀人才，深圳市孔雀團(tuán)隊(duì)核心成員，深圳市基因調(diào)控與系統(tǒng)生物學(xué)重點(diǎn)實(shí)驗(yàn)室核心PI。現(xiàn)任中國(guó)藥理學(xué)會(huì)抗炎免疫專(zhuān)委會(huì)委員、廣東省藥理學(xué)會(huì)理事、抗炎免疫專(zhuān)委會(huì)副主任委員、深圳市生物醫(yī)藥促進(jìn)會(huì)藥理研究與轉(zhuǎn)化應(yīng)用專(zhuān)委會(huì)常務(wù)委員。廣東歐美同學(xué)會(huì)常務(wù)理事。
教育背景：
2002.09-2006.06 德國(guó)馬普分子遺傳學(xué)研究所，功能基因組學(xué)，博士
1998.09-2001.06 華西醫(yī)科大學(xué)（后四川大學(xué)），藥學(xué)院，生藥學(xué)，碩士
1990.09-1994.06 成都中醫(yī)藥大學(xué)，中藥學(xué)，學(xué)士
工作經(jīng)歷：
2022.03-至今 南方科技大學(xué)醫(yī)學(xué)院藥理學(xué)系，副教授、研究員
2016.08-2022.03 南方科技大學(xué)生物系，獨(dú)立PI, 研究副教授，博士生導(dǎo)師
2009-2016 德國(guó)馬科斯?德?tīng)柌紖慰藝?guó)家分子醫(yī)學(xué)中心，高級(jí)研究員
2007-2009 德國(guó)馬普分子遺傳學(xué)研究所，青年科學(xué)家小組（化學(xué)及藥物基因組學(xué)）組長(zhǎng)
2006-2007 德國(guó)馬普分子遺傳學(xué)研究所，博士后
2002.1-2002.10 香港浸會(huì)大學(xué)，訪(fǎng)問(wèn)學(xué)者
1994-2002 華西醫(yī)科大學(xué)（2001年并入四川大學(xué)）藥學(xué)院，助教，講師（1999起)
獲獎(jiǎng)情況及榮譽(yù)：
2021年 深圳市產(chǎn)業(yè)發(fā)展與創(chuàng)新人才獎(jiǎng)
2020年 南方科技大學(xué)校優(yōu)秀專(zhuān)利獎(jiǎng)
研究領(lǐng)域：
1.基于功能基因組，特別是結(jié)合高通量測(cè)序、單細(xì)胞時(shí)空組學(xué)、CRISPR基因編輯技術(shù)的藥物功能和分子機(jī)制研究。
2. 基于精準(zhǔn)醫(yī)療的腫瘤基因組學(xué)和化學(xué)基因組學(xué)，致力于癌癥的耐藥逆轉(zhuǎn)、早期檢測(cè)和分類(lèi)靶向治療。
3.結(jié)合組學(xué)、化學(xué)生物學(xué)的細(xì)胞生物學(xué)研究。尤以化合物誘導(dǎo)的細(xì)胞焦亡、線(xiàn)粒體功能異常、DNA損傷和修復(fù)，及其在表觀(guān)遺傳學(xué)的改變?yōu)橹饕芯糠较颉?/p>
4. 基于新作用機(jī)理的化合物（含天然產(chǎn)物）臨床前新藥研發(fā)。
學(xué)術(shù)任職：
1、 擔(dān)任中國(guó)藥理學(xué)會(huì)抗炎免疫專(zhuān)委會(huì)委員；
2、 擔(dān)任廣東省藥理學(xué)會(huì)理事
3、擔(dān)任廣東省藥理學(xué)會(huì)抗炎免疫專(zhuān)委會(huì)副主任委員；
4、擔(dān)任中藥全球化聯(lián)盟會(huì)員；
5、擔(dān)任國(guó)際化學(xué)生物學(xué)學(xué)會(huì)會(huì)員；
6、擔(dān)任德中分子醫(yī)學(xué)和分子藥學(xué)學(xué)會(huì)會(huì)員；
7、擔(dān)任廣東歐美同學(xué)會(huì)常務(wù)理事
發(fā)表論文：
1. Liang W, Li G, Wang Y, Wei W, Chen R, Sun S, Gan D, Yi H, Schaefke B, Hu Y, Zhou Q, Li W, Cui H, Chen W. Evolutionary Analysis of Transcriptional Regulation Mediated by Cdx2 in Rodents. Cell Prolif. 2025 Jul 29:e70103. doi: 10.1111/cpr.70103.
2. Mingyue Wang, Qinan Hu, Zhencheng Tu, ..., Longqi Liu,*, Xun Xu,*, Yuhui Hu*. A Drosophila single-cell 3D spatiotemporal multi-omics atlas unveils panoramic key regulators of cell-type differentiation. Cell, 188（17）,4734-4753,2025, (Last-correspondence & lead-contact)
3. Haoyang Li, Qinan Hu, Zhaowen Qiu, Hui Xiong, Yuhui Hu*, Xin Gao,*. STP: single-cell partition for subcellular spatially-resolved transcriptomics. Nature Communications, 16, 4665 (2025). https://doi.org/10.1038/s41467-025-59782-3
4. Xiaojie Qiu, Daniel Y. Zhu, Yifan Lu, ..., Yuhui Hu, ..., Xun Xu*, Shiping Liu*, Yinqi Bai*. Spatiotemporal modeling of molecular holograms. Cell 187, 7351–7373, Dec. 2024. https://doi.org/10.1016/j.cell.2024.10.011
5. Y Zhao, C Kohl, D Rosebrock, Q Hu, Y Hu, M Vingron.*. CAbiNet: joint clustering and visualization of cells and genes for single-cell transcriptomics. Nucleic Acids Research, 2024, gkae480. https://doi.org/10.1093/nar/gkae480
6. Fang L, Zhang L, Wang M, He Y, Yang J, Huang Z, Tan Y, Fang K, Li J, Sun Z, Li Y, Tang Y, Liang W, Cui H, Zhu Q, Wu Z, Li Y, Hu Y, Chen W. Pooled CRISPR Screening Identifies P-Bodies as Repressors of Cancer Epithelial-Mesenchymal Transition. Cancer Res. 2024 Mar 4;84(5):659-674. https://doi.org/10.1158/0008-5472.CAN-23-1693.
7. Zhu, Q., Zhao, X., Zhang, Y….Hu, Y., Chen, A., Xu, X., Li, G., Hou, Y., Liu, L., Liu, S., Fang, L., Chen, W.*, Wu, L.*. Single cell multi-omics reveal intra-cell-line heterogeneity across human cancer cell lines. Nature Communications,14(1), 8170 (2023). https://doi.org/10.1038/s41467-023-43991-9
8. Mingyue Wang, Qinan Hu, Tianhang Lv, Yuhang Wang, Qing Lan, Zhencheng Tu, Rong Xiang, Yanrong Wei, Kai Han, Yanru An, Mengnan Cheng, Jiangshan Xu, Miguel A.Esteban, Haorong Lu, Wangsheng Li, Shaofang Zhang, Ao Chen, Wei Chen, Yuxiang Li, Xiaoshan Wang, Xun Xu*, Yuhui Hu*, Longqi Liu*. High-resolution 3D spatiotemporal transcriptomic maps of developing Drosophila embryos and larvae. Developmental cell，2022，Volume 57, Issue 10, Pages 1271-1283.e4. https://doi.org/10.1016/j.devcel.2022.04.006
9. Wencheng Wei, Yunfei Li, Chuanxi Wang, Sanxing Gao, Hao Wang, Yan Zhao, Ziying Gao, Yanxiang Jiang, Li Zhao, Hao Gao*, Xinsheng Yao, Yuhui Hu*. Diterpenoid Vinigrol specifically activates ATF4/DDIT3-mediated PERK arm of unfolded protein response to drive non-apoptotic death of breast cancer cells. Pharmacological Research, 2022, Volume 182, 106285. https://doi.org/10.1016/j.phrs.2022.106285
10. Zhongxiao Li, Yisheng Li, Bin Zhang, Yu Li, Yongkang Long, Juexiao Zhou, Xudong Zou, Min Zhang, Yuhui Hu*, Wei Chen*, Xin Gao*. DeeReCT-APA: Prediction of Alternative Polyadenylation Site Usage Through Deep Learning. Genomics Proteomics and Bioinformatics, (2022) Volume 20, Issue 3, Pages 483–495. https://doi.org/10.1016/j.gpb.2020.05.004
11. Huanhuan Cui, Hongyang Yi, Hongyu Bao, Ying Tan, Chi Tian, Xinyao Shi, Diwen Gan, Bin Zhang, Weizheng Liang, Rui Chen, Qionghua Zhu, Liang Fang, Xin Gao, Hongda Huang, Ruijun Tian, Silke R Sperling, Yuhui Hu, Wei Chen*.The SWI/SNF chromatin remodeling factor DPF3 regulates metastasis of ccRCC by modulating TGF-β signaling. Nat Commun 13(1), 4680 (2022). https://doi.org/10.1038/s41467-022-32472-0
12. Shuye Tian, Bin Zhang, Yuhao He, Zhiyuan Sun, Jun Li, Yisheng Li, Hongyang Yi, Yan Zhao, Xudong Zou, Yunfei Li, Huanhuan Cui, Liang Fang, Xin Gao, Yuhui Hu, Wei Chen*. CRISPR-iPAS: a novel dCAS13-based method for alternative polyadenylation interference. Nucleic Acids Research, 2022, gkac108.
13. Xudong Zou, Bernhard Schaefke, Yisheng Li, Fujian Jia, Wei Sun, Guipeng Li, Weizheng Liang, Tristan Reif, Florian Heyd, Qingsong Gao, Shuye Tian, Yanping Li, Yisen Tang, Liang Fang, Yuhui Hu, Wei Chen*. Mammalian splicing divergence is shaped by drift, buffering in trans, and a scaling law. Life Science Alliance (2021) 5(4):e202101333.
14. Yan Zhao, Jing Sun, Yunfei Li, Zhengxuan Li, Yu Xie, Ruoqing Feng, Jincun Zhao*, Yuhui Hu*. The strand-biased transcription of SARS-CoV-2 and unbalanced inhibition by remdesivir. iScience (2021)24 (8): 102857.
15. Liang Fang, Guipeng Li, Zhiyuan Sun, Qionghua Zhu, Huanhuan Cui, Yunfei Li, Jingwen Zhang, Weizheng Liang, Wencheng Wei, Yuhui Hu & Wei Chen*. CASB: a concanavalin A‐based sample barcoding strategy for single cell Sequencing. Molecular systems biology (2021) 17 (4): e10060.
16. Liang Fang*, Wen Wang, Guipeng Li, Li Zhang, Jun Li, Diwen Gan, Jiao Yang, Yisen Tang, Zewen Ding, Min Zhang, Wenhao Zhang, Daqi Deng, Zhengyu Song, Qionghua Zhu, Huanhuan Cui, Yuhui Hu and Wei Chen*. CIGAR‐seq, a CRISPR/Cas‐based method for unbiased screening of novel mRNA modification regulators. Mol Syst Biol (2020) 16:e10025.
17. Hongyang Yi, Guipeng Li, Yongkang Long, Weizheng Liang, Huanhuan Cui, Bin Zhang, Ying Tan, Yunfei Li, Luochen Shen, Daqi Deng, Yisen Tang, Chenyu Mao, Shuye Tian, Yunting Cai, Qionghua Zhu, Yuhui Hu*, Wei Chen* & Liang Fang*.Integrative multi-omics analysis of a colon cancer cell line with heterogeneous Wnt activity revealed RUNX2 as an epigenetic regulator of EMT. Oncogene (2020)39:5152–5164.
18. Yisheng Li , Bernhard Schaefke* , Xudong Zou, Min Zhang, Florian Heyd, Wei Sun, Bin Zhang, Guipeng Li, Weizheng Liang, Yuhao He, Juexiao Zhou, Yunfei Li, Liang Fang, Yuhui Hu & Wei Chen*. Pan-tissue analysis of allelic alternative polyadenylation suggests widespread functional regulation. Mol Syst Biol (2020) 16: e9367.
19. Xi Wang, Xintian You, Julian Langer, Jingyi Hou, Fiona Rupprecht, Irena Vlatkovic, Claudia Quedenau, Georgi Tushev, Irina Epstein, Bernhard Schaefke, Wei Sun, Liang Fang, Guipeng Li, Yuhui Hu, Erin Schuman, and Wei Chen. Full-length transcriptome reconstruction reveals a large diversity of RNA and protein isoforms in rat hippocampus. Nat Commun(2019) 10:5009.
20. Tao Chen, Bin Zhang, Thomas Ziegenhals, Archana B. Prusty, Sebastian Fro hler, Clemens Grimm, Yuhui Hu, Bernhard Schaefke, Liang Fang, Min Zhang, Nadine Kraemer, Angela M. Kaindl*, Utz Fischer*, and Wei Chen*. A missense mutation in SNRPElinked to non-syndromal microcephaly interferes with U snRNP assembly and pre-mRNA splicing. PLOS Genetics (2019) 15(10): e1008460.
21. Haiping Zhang, Linbu Liao, Yunting Cai, Yuhui Hu, Hao Wang*. IVS2vec: A tool of Inverse Virtual Screening based on word2vec and deep learning techniques, Methods (2019) 166:57–65.
22. Zhihao Xia, Yu Li , Bin Zhang, Zhongxiao Li, Yuhui Hu, Wei Chen*, and Xin Gao*. DeeReCT-PolyA: a robust and generic deep learning method for PAS identification. Bioinformatics (2019)35(14):2371–2379.
23. Wei Sun, Qingsong Gao, Bernhard Schaefke, Yuhui Hu, Wei Chen*. Pervasive allele-specific regulation on RNA decay in hybrid mice. Life science alliance (2018) 1 (2):e201800052.
24. Wang, Y., Gogol-D?ring, A., Hu, H., Fr?hler, S., Ma, Y., Jens, M., Maaskola, J., Murakawa, Y., Quedenau, C., Landthaler, M., Kalscheuer, V., Wieczorek, D., Wang, Y., Hu, Y.* and Chen, W.*. Integrative analysis revealed the molecular mechanism underlying RBM10-mediated splicing regulation. EMBO Mol Med. (2013) Sep;5(9):1431-42.
25. Mazin P, Xiong J, Liu X, Yan Z, Zhang X, Li M, He L, Somel M, Yuan Y, Phoebe Chen YP, Li N, Hu Y, Fu N, Ning Z, Zeng R, Yang H, Chen W*, Gelfand M*, Khaitovich P*. Widespread splicing changes in human brain development and aging. Mol Syst Biol. (2013); 9:633.
26. Li N, You X, Chen T, Mackowiak SD, Friedl?nder MR, Weigt M, Du H, Gogol-D?ring A, Chang Z, Dieterich C, Hu Y, Chen W*. Global profiling of miRNAs and the hairpin precursors: insights into miRNA processing and novel miRNA discovery. Nucleic Acids Res. (2013) Apr 1;41(6):3619-34.
27. Thu-Hang Pham, Christopher Benner, Monika Lichtinger, Lucia Schwarzfischer, Yuhui Hu, Reinhard Andreesen, Wei Chen and Michael Rehli. Dynamic epigenetic enhancer signatures reveal key transcription factors associated with monocytic differentiation states. Blood.(2012) Jun 14;119(24):e161-71.
28. Liu X, Somel M, Tang L, Yan Z, Jiang X, Guo S, Yuan Y, He L, Oleksiak A, Zhang Y, Li N, Hu Y, Chen W, Qiu Z, P??bo S, Khaitovich P. Extension of cortical synaptic development distinguishes humans from chimpanzees and macaques. Genome Res. (2012) Apr;22(4):611-22.
29. Somel M, Liu X, Tang L, Yan Z, Hu H, Guo S, Jiang X, Zhang X, Xu G, Xie G, Li N, Hu Y, Chen W, P??bo S, Khaitovich P. MicroRNA-Driven Developmental Remodeling in the Brain Distinguishes Humans from Other Primates. PLoS Biol. (2011) Dec;9(12):e1001214.
30. Zheng Yan, Hai Yang Hu, Xi Jiang, Vera Maierhofer, Elena Neb, Liu He, Yuhui Hu, Hao Hu, Na Li, Wei Chen, and Philipp Khaitovich. Widespread expression of piRNA-like molecules in somatic tissues. Nucleic Acids Res. (2011) Aug;39(15):6596-607.
31. Yuhui Hu and Michal Janitz. High-throughput subcellular protein localization using transfected-cell arrays. Methods Mol Biol. (2011);706:53-72.
32. Mehmet Somel, Song Guo, Ning Fu, Zheng Yan, Hai Yang Hu, Ying Xu, Yuan Yuan, Zhibin Ning, Yuhui Hu, Corinna Menzel, Hao Hu, Michael Lachmann, Rong Zeng, Wei Chen, and Philipp Khaitovich. MicroRNA, mRNA, and protein expression link development and aging in human and macaque brain. Genome Research (2010); 20:1207-1218.
33. Weimin Qiu, Yuhui Hu, Tom E. Andersen, Abbas Jafari, Na Li, Wei Chen, and Moustapha Kassem. Tumor necrosis factor receptor superfamily member 19 (TNFRSF19) regulates differentiation fate of human mesenchymal (stromal) stem cells through canonical WNT signaling and C/EBP. J Biol Chem. (2010); 7;285(19):14438-49.
34. Yuhui Hu, Hans Lehrach and Michal Janitz. Apoptosis screening of human chromosome 21 proteins reveals novel cell death regulators. Molecular Biology Reports (2010); 37(7): 3381–3387.
35. Chen W, Ullmann R, Langnick C, Menzel C, Wotschofsky Z, Hu H, D?ring A, Hu Y, Kang H, Tzschach A, Hoeltzenbein M, Neitzel H, Markus S,Wiedersberg E, Kistner G, van Ravenswaaij-Arts CM, Kleefstra T, Kalscheuer VM, Ropers HH. Breakpoint analysis of balanced chromosome rearrangements by next-generation paired-end sequencing. Eur J Hum Genet. (2010) May;18(5):539-43.
36. Yuhui Hu, Hans Lehrach and Michal Janitz. Comparative analysis of an experimental subcellular protein localization assay and in silico prediction methods. Journal of Molecular Histology. (2009) Oct;40(5-6):343-52.
37. Fiebitz A, Nyarsik L, Haendler B, Hu YH, Wagner F, Thamm S, Lehrach H, Janitz M, Vanhecke D. High-throughput mammalian two-hybrid screening for protein-protein interactions using transfected cell arrays. BMC Genomics (2008), 9:68.
38. H. Hu, H. J. Warnatz, D. Vanhecke, F. Wagner, A. Fiebitz, S. Thamm, P. Kahlem, H. Lehrach, M. L. Yaspo, and M. Janitz. Cell array-based intracellular localization screening reveals novel functional features of human chromosome 21 proteins. BMC Genomics (2006), 7:155.
39. H. Hu, D. Vanhecke, M. Janitz. High-throughput subcellular protein localization using cell arrays. Biochemical Society Transaction. (2005) Dec;33(Pt 6):1407-8.
40. Liu L, Han L, Wong DYL, Yue PYK, Ha WY, Hu YH, Wang PX, Wong RNS. Effects of Si-Jun-Zi decoction polysaccharides on cell migration and gene expression in wounded rat intestinal epithelial cells. British Journal of Nutrition. (2005) 93, 21–29.
41. Hu Yuhui, ZHANG Hao, Zhang Zhi-Feng. Determine total flavonoids and scutellarin of Erigeron genus. J. Pharm. Anal. (2005) 25(1).
42. Hu Yuhui, ZHANG Hao. Chemical comparative study on the active compounds in 5 species of Erigeron. The journal of Chinese Traditional Patent Medicine (2004) Jan.
43. 張志鋒，張浩，胡宇慧，劉顯福。不同產(chǎn)地多舌飛蓬化學(xué)成分的含量測(cè)定?！吨袊?guó)民族民間醫(yī)藥雜志》，2003年 2期
44. 胡宇慧，張浩等。歐洲兩地和中國(guó)西南山區(qū)飛蓬揮發(fā)油成份的比較?！度A西藥學(xué)雜志》， 2001年16卷3期