師資
個(gè)人簡(jiǎn)介：
陳默，醫(yī)學(xué)院藥理學(xué)系研究員、副教授、南方科技大學(xué)穩(wěn)態(tài)醫(yī)學(xué)研究院院長(zhǎng)助理、博士生導(dǎo)師。入選國(guó)家級(jí)高層次青年人才項(xiàng)目，深圳市鵬城孔雀特聘專家。2013年于新加坡國(guó)立大學(xué)（National University of Singapore）獲得博士學(xué)位，2014至2017年于新加坡國(guó)立大學(xué)從事博士后研究。2017至2023年于美國(guó)威斯康星大學(xué)麥迪遜分校（University of Wisconsin Madison）相繼任博士后和研究員。主要研究方向聚焦于細(xì)胞生物學(xué)、脂質(zhì)生物學(xué)、磷酸肌醇信號(hào)通路、糖脂代謝與相關(guān)疾病分子機(jī)制。主持國(guó)家自然科學(xué)基金項(xiàng)目、廣東省基礎(chǔ)與應(yīng)用基礎(chǔ)研究基金委員會(huì)區(qū)域聯(lián)合基金項(xiàng)目、SMART深圳市醫(yī)學(xué)研究專項(xiàng)資金項(xiàng)目、深圳市基礎(chǔ)研究專項(xiàng)（自然科學(xué)基金）面上項(xiàng)目。代表性成果以通訊/第一作者（含共同）發(fā)表在Nature Cell Biology（四篇：2019、2020、2022、2025）、Trends in Cell Biology、Cell Death & Differentiation（兩篇: 2014、2018）、Protein & Cell、Cell Death & Disease、BBA-Molecular and Cell Biology of Lipids、Oral Science and Homeostatic Medicine、Journal of Hazardous Materials、Methods in Molecular Biology等國(guó)際知名期刊及叢書上，累計(jì)發(fā)表論文30篇。
教育背景：
2009-08 至 2013-12 新加坡國(guó)立大學(xué)，生物學(xué)，博士
2005-09 至 2009-06 四川大學(xué)，生物技術(shù)，學(xué)士
工作經(jīng)歷：
2024-01至今 南方科技大學(xué)醫(yī)學(xué)院藥理學(xué)系，副教授
2023-04至 2023-12 南方科技大學(xué)醫(yī)學(xué)院藥理學(xué)系，助理教授
2022-07至 2023-03 美國(guó)威斯康星大學(xué)麥迪遜分校醫(yī)學(xué)院, Senior Scientist
2019-09至 2022-07 美國(guó)威斯康星大學(xué)麥迪遜分校醫(yī)學(xué)院, Associate Scientist
2017-07至 2019-09 美國(guó)威斯康星大學(xué)麥迪遜分校醫(yī)學(xué)院, 博士后
2014-01至 2017-06 新加坡國(guó)立大學(xué)生物系，博士后
獲獎(jiǎng)情況及榮譽(yù)：
2015 新加坡心血管協(xié)會(huì)優(yōu)秀青年學(xué)者獎(jiǎng)勵(lì)
2009-2013 新加坡國(guó)立大學(xué)全額獎(jiǎng)學(xué)金
2009 四川省優(yōu)秀大學(xué)畢業(yè)生
2007 國(guó)家獎(jiǎng)學(xué)金
學(xué)術(shù)任職：
1. Oral Science and Homeostatic Medicine編委會(huì)委員
2. Experimental and Molecular Pathology編委會(huì)委員
3. Journal of Translational Internal Medicine青年編委
4. 中國(guó)藥理學(xué)會(huì)抗炎免疫藥理專業(yè)委員會(huì)第十三屆委員會(huì)委員
5. 廣東省藥理學(xué)會(huì)神經(jīng)藥理專委會(huì)委員
研究領(lǐng)域：
本課題組主要利用生物化學(xué)、細(xì)胞生物學(xué)、分子生物學(xué)、質(zhì)譜等多種方法來(lái)研究磷酸肌醇信號(hào)調(diào)控、物質(zhì)運(yùn)輸、糖脂與效應(yīng)蛋白的復(fù)合及生物學(xué)功能，了解脂質(zhì)在細(xì)胞器中非膜結(jié)構(gòu)上的定位以及作用機(jī)理，解析疾病中的糖脂代謝功能異常并以此為靶點(diǎn)開發(fā)新型藥物。
發(fā)表論文：
1. Hou, X., Ren, C., Jin, J., Chen, Y., Lyu, X., Bi, K., Carrillo, N.D., Cryns, V.L., Anderson, R.A., Sun, J.* & Chen, M.* Phosphoinositide signalling in cell motility and adhesion. Nature Cell Biology 27, 736-748 (2025).
2. Sun, J.* & Chen, M.* Navigating AKT-ivity across cellular compartments. Trends in Cell Biology (2025).
3. Zhou, B.#, Feng, Y.#, Liang, J., Lu, Z., Zhang, S., Wang, X., Zhang, R., Shuai, S., Wang, S.* & Chen, M.* Pip5k1a regulates mandibular homeostasis by orchestrating osteogenesis in mice. Oral Science and Homeostatic Medicine (2025).
4. Hou, X.#, Chen, Y.#, Zhou, B.#, Liu, F., Dai, L., Chen, C., Carrillo, N.D., Cryns, V.L., Anderson, R.A., Sun, J.* & Chen, M.* The nuclear phosphoinositide-p53 signalosome in the regulation of cell motility. Protein & Cell (2025).
5. Hou, X.#, Chen, Y.#, Carrillo, N.D., Cryns, V.L., Anderson, R.A., Sun, J., Wang, S.* & Chen, M.* Phosphoinositide signaling at the cytoskeleton in the regulation of cell dynamics. Cell Death & Disease 16, 296 (2025).
6. Chen, M.*, Tan, J.X., Sun, Y., Thapa, N., Cryns, V.L. & Anderson, R.A.* Agonist- and stress-driven compartmentalized phosphoinositide signaling in cells. Biochimica et Biophysica Acta (BBA)-Molecular and Cell Biology of Lipids 1870, 159662 (2025).
7. Ren, C.#, Liu, F.#, Li, X., Zhang, Y., Liu, X., Wang, J.*, Sun, J.* & Chen, M.* Decoding phosphoinositide signaling in viral pathogenesis and autoimmune disorders. Microbes & Immunity, in press (2025).
8. Ren, C., Carrillo, N.D., Cryns, V.L., Anderson, R.A. & Chen, M.* Environmental pollutants and phosphoinositide signaling in autoimmunity. Journal of Hazardous Materials 465, 133080 (2024).
9. Chen, M., Choi, S., Wen, T., Chen, C., Thapa, N., Lee, J.H., Cryns, V.L.* & Anderson, R.A.* A p53-phosphoinositide signalosome regulates nuclear AKT activation. Nature Cell Biology 24, 1099-1113 (2022).
10. Thapa, N.#, Chen, M.#, Horn, H.T., Choi, S., Wen, T. & Anderson, R.A.* Phosphatidylinositol-3 kinase signalling is spatially organized at endosomal compartments by microtubule-associated protein 4. Nature Cell Biology 22, 1357-1370 (2020).
11. Choi, S.#, Chen, M.#, Cryns, V.L. & Anderson, R.A.* A nuclear phosphoinositide kinase complex regulates p53. Nature Cell Biology 21, 462-475 (2019).
12. Chen, M., Qiu, T., Wu, J., Yang, Y., Wright, G.D., Wu, M. & Ge, R.* Extracellular anti-angiogenic proteins augment an endosomal protein trafficking pathway to reach mitochondria and execute apoptosis in HUVECs. Cell Death & Differentiation 25, 1905-1920 (2018).
13. Chen, M., Zhang, Y., Yu, V.C., Chong, Y.S., Yoshioka, T. & Ge, R.* Isthmin targets cell-surface GRP78 and triggers apoptosis via induction of mitochondrial dysfunction. Cell Death & Differentiation 21, 797-810 (2014).
14. Chen, M., Wen, T., Horn, H.T., Chandrahas, V.K., Thapa, N., Choi, S., Cryns, V.L. & Anderson, R.A.* The nuclear phosphoinositide response to stress. Cell Cycle 19, 268-289 (2020).
15. Chen, M., Horn, H.T., Wen, T., Cryns, V.L. & Anderson, R.A.* Assessing in situ phosphoinositide-protein interactions through fluorescence proximity ligation assay in cultured cells. Methods in Molecular Biology 2251, 133-142 (2021).
16. Thapa, N., Chen, M., Cryns, V.L.* & Anderson, R.A.* A p85 isoform switch enhances PI3K activation on endosomes by a MAP4- and PI3P-dependent mechanism. Cell Reports 43, 114119 (2024).
17. Lee, J.H., Chen, M., Wen, T., Anderson, R.A.* & Cryns, V.L.* Regulation of the MDM2-p53 nexus by a nuclear phosphoinositide and small heat shock protein complex. Journal of Biological Chemistry 301, 110527 (2025).
18. Wen, T., Chen, M., Cryns, V.L.* & Anderson, R.A.* The poly(A) polymerase Star-PAP is regulated by stably associated phosphoinositide messengers. Journal of Biological Chemistry 301, 110412 (2025).
19. Chen, C., Carrillo, N.D., Chen, M., Wen, T., Awasthi, P., Anderson, R.A.* & Cryns, V.L.* Regulation of NRF2 by stably associated phosphoinositides and small heat shock proteins in response to stress. Journal of Biological Chemistry 301, 110367 (2025).
20. Zhang, D., Li, S., Wang, Y., Zhang, Z., Xu, H., Wu, S., Jin, H., Han, X., Liu, Y., Wen, X., Wu, Y., Zhang, Z., Hu, L., Hu, L., Zhang, C., Wang, J., Yan, R., Chen, M., Xiao, G., Sun, G. & Wang, S.* Sodium nitrate protects against metabolic syndrome by sialin-mediated macrophage rebalance. Signal Transduction and Targeted Therapy, in press (2025).
（#共同一作，*通訊作者）