師資
個(gè)人簡介：
蘇明媛，南方科技大學(xué)醫(yī)學(xué)院副教授、研究員，博士生導(dǎo)師。2012年和2015年先后在臺(tái)灣大學(xué)獲得生化科學(xué)碩士和博士學(xué)位，2016-2021年在美國加州大學(xué)伯克利分校的Dr. James H. Hurley實(shí)驗(yàn)室進(jìn)行博士后研究，期間榮獲AFTD Basic Science Postdoctoral Fellowship。2021年5月全職加入南科大醫(yī)學(xué)院。近年來以第一/通訊作者在Nature，NSMB，Molecular cell，Nature Communications, Science Advances，Cell Reports 等國際學(xué)術(shù)期刊發(fā)表文章。Nature Communications, Cell Press, Cell Discovery, eLife 和Cell Reports 期刊審稿人。
教育背景：
2012-08至2015-08, 臺(tái)灣大學(xué), 生化科學(xué), 博士
2010-08至2012-07, 臺(tái)灣大學(xué), 生化科學(xué), 碩士
2005-08至2009-07, 臺(tái)灣大學(xué), 化學(xué), 學(xué)士
工作經(jīng)歷：
2022-06至今 ， 南方科技大學(xué)醫(yī)學(xué)院，副教授
2021-05至2022-05 ，南方科技大學(xué)醫(yī)學(xué)院，助理教授
2016-08至2021-03, 美國加州大學(xué)伯克利分校/勞倫斯伯克利國家實(shí)驗(yàn)室, 博士后
2015-09至2016-07, 中央研究院生化科學(xué)研究所, 博士后
獲獎(jiǎng)情況及榮譽(yù)：
2019-2021 AFTD Basic Science Postdoctoral Fellowship
2016-2017 臺(tái)灣中央研究院-博士后研究學(xué)者
2012-2014 澳門研究生資助發(fā)放技術(shù)委員會(huì)-研究生獎(jiǎng)學(xué)金
2011,2013 臺(tái)灣大學(xué)-研究所優(yōu)秀僑生獎(jiǎng)學(xué)金
2012 臺(tái)灣大學(xué)生命科學(xué)院-院長獎(jiǎng)
2005-2009 澳門教育暨青年局-大專獎(jiǎng)助學(xué)金
研究領(lǐng)域：
課題組利用生物化學(xué)、細(xì)胞生物學(xué)、結(jié)構(gòu)質(zhì)譜學(xué)以及蛋白質(zhì)結(jié)構(gòu)解析技術(shù)研究：
1）溶酶體生物學(xué)相關(guān)的生物大分子結(jié)構(gòu)和功能機(jī)制；
2）蛋白質(zhì)穩(wěn)態(tài)調(diào)控通路中的重要蛋白質(zhì)結(jié)構(gòu)解析、功能研究和轉(zhuǎn)化應(yīng)用
發(fā)表論文：
After 2021:
8. Su M-Y*,#, Teng F*, Wang S*, Mai X, Zeng H, Li J, Song X, Wang X and Stjepanovic G. Cryo-EM structures of amino acid sensors bound to the human GATOR2 complex. Cell Reports. 2025. https://doi.org/10.1016/j.celrep.2025.116088. (*equal contribution)
7. Zhang J*, Chen C*, Chen X*, Liao K, Li F, Song X, Liu C, Su M-Y, Sun H, Hou T, Tan C, Fang L#, Rao H#. Linker-free PROTACs efficiently induce the degradation of oncoproteins. Nat Commun. 2025 May 23;16(1):4794. (*equal contribution)
6. Wang Y, Liu M, Wang S, Mai X, Wang X, Teng F, Lyn T, Su M-Y#, Stjepanovic G#. Mechanism of D-type cyclin recognition by the AMBRA1 E3 ligase receptor. Sci Adv. 2025 May 23;11(21):eadu8708.
5. Zhang J, Chen X, Chen C, Li F, Song X, Liu C, Liao K, Su M-Y, Tan CSH, Fang L, Rao H. Distinct Amino Acid-Based PROTACs Target Oncogenic Kinases for Degradation in Non-Small Cell Lung Cancer (NSCLC). J Med Chem. 2024, 67(16):13666-13680.
4. Mai X, Wang Y, Wang X, Liu M, Teng F, Liu Z, Su M-Y#, Stjepanovic G#. Structural basis for membrane remodelling by the AP5:SPG11-SPG15 complex. Nature Structural & Molecular Biology. 2025. 10.1038/s41594-025-01500-0
3. Teng F*, Wang Y*, Liu M, Tian S, Stjepanovic G#, Su M-Y#. 2023. Cryo-EM structure of the KLHL22 E3 ligase bound to an oligomeric metabolic enzyme. Structure 31, 1431-1440 e1435. (*equal contribution)
2. Liu M, Wang Y, Teng F, Wang X, Mai X, Su M-Y#, Stjepanovic G#. 2023. Structural basis for substrate recruitment by AMBRA1 E3 ligase receptor. Nat Commun. 2023 Nov 22;14(1):7631.
1. Su M-Y, Fromm SA, Remis J, Toso DB, Hurley JH. 2021. Structural basis for the ARF GAP activity and specificity of the C9orf72 complex. Nature Communications 12(1):3786.
Before 2021:
1. Su M-Y, Fromm SA, Zoncu R, Hurley JH. 2020. Structure of the C9orf72 Arf GAP complex haploinsufficient in ALS and FTD. Nature 585(7824):251-255.
2. Turco E*, Witt M*, Abert C*, Bock-Bierbaum T*, Su M-Y*, Trapannone R, Sztacho M, Danieli A, Shi X, Zaffagnini G, GamperA, Schuschnig M, Fracchiolla D, Bernklau D, Romanov J, Hartl M, Hurley JH, Daumke O, Martens S. 2019. FIP200 Claw Domain Binding to p62 Promotes Autophagosome Formation at Ubiquitin Condensates. Mol Cell 74:330-346.e11. (*equal contribution)
3. Turco E, Witt M, Abert C, Bock-Bierbaum T, Su M-Y, Trapannone R, Sztacho M, Danieli A, Shi X, Zaffagnini G, Gamper A, Schuschnig M, Fracchiolla D, Bernklau D, Romanov J, Hartl M, Hurley JH, Daumke O, Martens S. 2019. How RB1CC1/FIP200 claws its way to autophagic engulfment of SQSTM1/p62-ubiquitin condensates. Autophagy 15:1475–1477.
4. Su M-Y, Morris KL, Kim DJ, Fu Y, Lawrence R, Stjepanovic G, Zoncu R, Hurley JH. 2017. Hybrid Structure of the RagA/CRagulator mTORC1 Activation Complex. Mol Cell 68:835-846.e3.
5. Su M-Y, Som N, Wu C-Y, Su S-C, Kuo Y-T, Ke L-C, Ho M-R, Tzeng S-R, Teng C-H, Mengin-Lecreulx D, Reddy M, Chang C-I. 2017. Structural basis of adaptor-mediated protein degradation by the tail-specific PDZ-protease Prc. Nat Commun 8:1516.
6. Lin C-C, Su S-C, Su M-Y, Liang P-H, Feng C-C, Wu S-H, Chang C-I. 2016. Structural Insights into the Allosteric Operation of the Lon AAA+ Protease. Structure 24:667–675.
7. Su M-Y, Peng W-H, Ho M-R, Su S-C, Chang Y-C, Chen G-C, Chang C-I. 2015. Structure of yeast Ape1 and its role in autophagic vesicle formation. Autophagy 11:1580–1593.
8. Chao S-W, Su M-Y, Chiou L-C, Chen L-C, Chang C-I, Huang W-J. 2015. Total Synthesis of Hispidulin and the Structural Basis for Its Inhibition of Proto-oncogene Kinase Pim-1. J Nat Prod 78:1969–1976.
9. Su M-Y, Chang C-I, Chang C-F. 2013. 1H, 13C and 15N resonance assignments of the pyrin domain from human PYNOD. Biomol NMR Assign 7:141–143.
10. Su M-Y, Kuo C-I, Chang C-F, Chang C-I. 2013. Three-dimensional structure of human NLRP10/PYNOD pyrin domain reveals a homotypic interaction site distinct from its mouse homologue. PLoS ONE 8:e67843.