師資
· 姓名：鄭梅珍
· 職位：助理教授
· Email：zhengmz@sustech.edu.cn
· ORCID: 0000-0003-2934-4088
· 個(gè)人主頁(yè)：http://faculty.sustech.edu.cn/zhengmz/
· 實(shí)驗(yàn)室主頁(yè)：https://www.zhengmzlab.com/
個(gè)人簡(jiǎn)介
鄭梅珍博士2001年畢業(yè)于華中科技大學(xué)同濟(jì)醫(yī)學(xué)院，2004年獲暨南大學(xué)生物化學(xué)與分子生物學(xué)碩士學(xué)位，2007年于中山大學(xué)附屬腫瘤防治中心取得腫瘤學(xué)博士學(xué)位。博士畢業(yè)后先后在新加坡基因組研究所（GIS）及美國(guó)杰克遜實(shí)驗(yàn)室基因組醫(yī)學(xué)中心（The Jackson Laboratory for Genomic Medicine）從事博士后及副研究員工作，期間參與 ENCODE 和 4D Nucleome 等國(guó)際重大項(xiàng)目。2019年底加入南方科技大學(xué)生命科學(xué)學(xué)院，成立三維基因組學(xué)實(shí)驗(yàn)室。深圳市國(guó)家級(jí)領(lǐng)軍人才。以第一作者或通訊作者身份在 Nature, Science Advances, The EMBO Journal, Briefings in Bioinformatics 等國(guó)際權(quán)威期刊發(fā)表多篇研究性論文。主持/參與科技部、國(guó)家、省、市基金多項(xiàng)；獲批專利4項(xiàng)。擔(dān)任 Genome Biology, Nucleic Acids Research, Journal of Genetics and Genomics, Genomics, Proteomics & Bioinformatics 等期刊審稿人和基金評(píng)審人。廣東省精準(zhǔn)醫(yī)學(xué)應(yīng)用學(xué)會(huì)單細(xì)胞技術(shù)分會(huì)第一屆委員會(huì)委員；中國(guó)遺傳學(xué)會(huì)三維基因組學(xué)專業(yè)委員會(huì)委員；國(guó)際三維基因組學(xué)研討會(huì)學(xué)術(shù)委員。
研究領(lǐng)域
鄭梅珍實(shí)驗(yàn)室專注于單細(xì)胞及單分子水平的三維基因組學(xué)前沿技術(shù)開(kāi)發(fā)與應(yīng)用，致力于揭示染色質(zhì)高級(jí)結(jié)構(gòu)與基因轉(zhuǎn)錄調(diào)控之間的空間動(dòng)態(tài)關(guān)系。實(shí)驗(yàn)室核心研究方向包括：
· 高分辨率三維基因組技術(shù)開(kāi)發(fā)與應(yīng)用 （如RDD, Science Advances ;ChIA-Drop, Nature）
· 單細(xì)胞多組學(xué)技術(shù)開(kāi)發(fā)與應(yīng)用（如scAIR, Science Advances）
· 智能化數(shù)據(jù)分析與可視化平臺(tái)建設(shè)（如ScSmOP, MCIBox, BIB 2022,2023）
工作經(jīng)歷
· 2019年 – 至今 南方科技大學(xué) 助理教授
· 2012年 – 2019年 美國(guó)杰克遜實(shí)驗(yàn)室基因組醫(yī)學(xué)中心 博士后、副研究員
· 2010年 – 2012年 新加坡基因組研究院 博士后
· 2007年 – 2009年 東華大學(xué) 博士后
教育經(jīng)歷
· 2004年 – 2007年 中山大學(xué)附屬腫瘤防治中心 腫瘤學(xué) 博士
· 2001年 – 2004年 暨南大學(xué)醫(yī)學(xué)院 生物化學(xué)與分子生物學(xué) 碩士
· 1995年 – 2001年 華中科技大學(xué)同濟(jì)醫(yī)學(xué)院 臨床醫(yī)療 學(xué)士
代表論文
最后通訊作者：
1: Tian, Simon Zhongyuan#,*; Yang, Yang#; Ning, Duo#; Yu, Ting#; Gao, Tong; Deng, Yuqing; Fang, Ke; Xu, Yewen; Jing, Kai; Huang, Guangyu; Chen, Gengzhan; Yin, Pengfei; Li, Yiming; Zeng, Fuxing*; Tian, Ruilin*; Zheng, Meizhen*. Landscape of the Epstein-Barr virus-host chromatin interactome and gene regulation. The EMBO Journal, 2025, 1–44.
2: Tian, Simon Zhongyuan#,*; Yang, Yang#; Ning, Duo#; Fang, Ke#; Jing, Kai; Huang, Guangyu; Xu, Yewen; Yin, Pengfei; Huang, Haibo; Chen, Gengzhan; Deng, Yuqing; Zhang, Shaohong; Zhang, Zhimin; Chen, Zhenxia; Gao, Tong; Chen, Wei; Li, Guoliang; Tian, Ruilin; Ruan, Yijun*; Li, Yiming*; Zheng, Meizhen*. 3D chromatin structures associated with ncRNA roX2 for hyperactivation and coactivation across the entire X chromosome. Science Advances, 2024, 10(30): eado5716.
3: Yang, Yang; Chen, Gengzhan; Gao, Tong; Ning, Duo; Deng, Yuqing; Tian, Simon Zhongyuan*; Zheng, Meizhen*. Tn5-Labeled DNA-FISH: An Optimized Probe Preparation Method for Probing Genome Architecture. International Journal of Molecular Sciences, 2025, 26(5): 2224.
4: Ning, Duo; Deng, Yuqing; Gao, Tong; Yang, Yang; Chen, Gengzhan; Tian, Simon Zhongyuan*; Zheng, Meizhen*. TF-chRDP: a method for simultaneously capturing transcription factor binding chromatin-associated RNA, DNA and protein. Frontiers in Cell and Developmental Biology, 2025, 13: 1561540.
5: Jing, Kai; Xu, Yewen; Yang, Yang; Yin, Pengfei; Ning, Duo; Huang, Guangyu; Deng, Yuqing; Chen, Gengzhan; Li, Guoliang; Tian, Simon Zhongyuan*; Zheng, Meizhen*. ScSmOP: a universal computational pipeline for single-cell single-molecule multiomics data analysis. Briefings in Bioinformatics, 2023, 24(6): bbad343.
6: Tian, Simon Zhongyuan*; Li, Guoliang; Ning, Duo; Jing, Kai; Xu, Yewen; Yang, Yang; Fullwood, Melissa J; Yin, Pengfei; Huang, Guangyu; Plewczynski, Dariusz; Zhai, Jixian; Dai, Ziwei; Chen, Wei; Zheng, Meizhen*. MCIBox: a toolkit for single-molecule multi-way chromatin interaction visualization and micro-domains identification. Briefings in Bioinformatics, 2022, 23(6): bbac380.
7: Tian, Simon Zhongyuan*; Yin, Pengfei; Jing, Kai; Yang, Yang; Xu, Yewen; Huang, Guangyu; Ning, Duo; Fullwood, Melissa J*; Zheng, Meizhen*. MCI-frcnn: A deep learning method for topological micro-domain boundary detection. Frontiers in Cell and Developmental Biology, 2022, 10: 1050769.
第一作者：
8: Zheng, Meizhen; Tian, Simon Zhongyuan; Capurso, Daniel; Kim, Minji; Maurya, Rahul; Lee, Byoungkoo; Piecuch, Emaly; Gong, Liang; Zhu, Jacqueline Jufen; Li, Zhihui; Wong, Chee Hong; Ngan, Chew Yee; Wang, Ping; Ruan, Xiaoan; Wei, Chia-Lin; Ruan, Yijun*. Multiplex chromatin interactions with single-molecule precision. Nature, 2019, 566(7745): 558-562.
9: Zheng, Meizhen; Zheng, L-M; Zeng, Yi-Xin*. SCC-112 gene is involved in tumor progression and promotes the cell proliferation in G2/M phase. Journal of Cancer Research and Clinical Oncology, 2008, 134: 453-462.
10: Zheng, Meizhen; Qin, Hai-De; Yu, Xing-Juan; Zhang, Ru-Hua; Chen, Li-Zhen; Feng, Qi-Sheng; Zeng, Yi-Xin*. Haplotype of gene Nedd4 binding protein 2 associated with sporadic nasopharyngeal carcinoma in the Southern Chinese population. Journal of Translational Medicine, 2007, 5: 7.
11: Zheng, Meizhen; Jiang, Jianwei*. Progress in unmethylated immunostimulatory oligodeoxynucletides. Progress in Biochemistry and Biophysics, 2003, 30(2): 190-193.
共同作者：
12: Chen, Rui; Shi, Xinyao; Yao, Xiangrui; Gao, Tong; Huang, Guangyu; Ning, Duo; Cao, Zemin; Xu, Youxin; Liang, Weizheng; Tian, Simon Zhongyuan; Zhu, Qionghua; Fang, Liang; Zheng, Meizhen; Hu, Yuhui; Cui, Huanhuan*; Chen, Wei*. Specific multivalent molecules boost CRISPR-mediated transcriptional activation. Nature Communications, 2024, 15(1): 7222.
13: Li, Zhuowen#; Long, Yanping#; Yu, Yiming; Zhang, Fei; Zhang, Hong; Liu, Zhijian; Jia, Jinbu; Mo, Weipeng; Tian, Simon Zhongyuan; Zheng, Meizhen; Zhai, Jixian*. Pore-C simultaneously captures genome-wide multi-way chromatin interaction and associated DNA methylation status in Arabidopsis. Plant Biotechnology Journal, 2022, 20(6): 1009.
14: Chen, Tao#; Lin, Yu-Xin#; Zha, Yan#; Sun, Ying; Tian, Jinxiu; Yang, Zhiying; Lin, Shan-Wen; Yu, Fuxun; Chen, Zi-Sheng; Kuang, Bo-Hua; Lei, Jin-Ju; Nie, Ying-Jie; Xu, Yonghao; Tian, Dong-Bo; Li, Ying-Zi; Yang, Bin; Xu, Qiang; Yang, Li; Zhong, Nanshan; Zheng, Meizhen; Li, Yimin; Zhao, Jincun; Zhang, Xiang-Yan; Feng, Lin*. A low-producing haplotype of interleukin-6 disrupting CTCF binding is protective against severe COVID-19. MBio, 2021, 12(5).
15: Wang, Ping#; Tang, Zhonghui#; Lee, Byoungkoo; Zhu, Jacqueline Jufen; Cai, Liuyang; Szalaj, Przemyslaw; Tian, Simon Zhongyuan; Zheng, Meizhen; Plewczynski, Dariusz; Ruan, Xiaoan; Liu, Edison T; Wei, Chia-Lin; Ruan, Yijun*. Chromatin topology reorganization and transcription repression by PML-RARα in acute promyeloid leukemia. Genome Biology, 2020, 21: Jan-21.
16: Kim, Minji; Zheng, Meizhen; Tian, Simon Zhongyuan; Lee, Byoungkoo; Chuang, Jeffrey H; Ruan, Yijun*. MIA-Sig: multiplex chromatin interaction analysis by signal processing and statistical algorithms. Genome Biology, 2019, 20: Jan-13.
17: Li, Xingwang#; Luo, Oscar Junhong#; Wang, Ping; Zheng, Meizhen; Wang, Danjuan; Piecuch, Emaly; Zhu, Jacqueline Jufen; Tian, Simon Zhongyuan; Tang, Zhonghui; Li, Guoliang; Ruan, Yijun*. Long-read ChIA-PET for base-pair-resolution mapping of haplotype-specific chromatin interactions. Nature Protocols, 2017, 12(5): 899-915.
18: Dekker, Job; Belmont, Andrew S; Guttman, Mitchell; Leshyk, Victor O; Lis, John T; Lomvardas, Stavros; Mirny, Leonid A; O’Shea, Clodagh C; Park, Peter J; Ren, Bing; Politz, Joan C Ritland; Shendure, Jay; Zhong, Sheng; 4D Nucleome Network. The 4D nucleome project. Nature, 2017, 549(7671): 219-226. *** Zheng, Meizhen is a member of the 4D Nucleome Network***
19: Tang, Zhonghui#; Luo, Oscar Junhong#; Li, Xingwang#; Zheng, Meizhen; Zhu, Jacqueline Jufen; Szalaj, Przemyslaw; Trzaskoma, Pawel; Magalska, Adriana; Wlodarczyk, Jakub; Ruszczycki, Blazej; Michalski, Paul; Piecuch, Emaly; Wang, Ping; Wang, Danjuan; Tian, Simon Zhongyuan; Penrad-Mobayed, May; Sachs, Laurent M; Ruan, Xiaoan; Wei, Chia-Lin; Liu, Edison T; Wilczynski, Grzegorz M; Plewczynski, Dariusz; Li, Guoliang; Ruan, Yijun*. CTCF-mediated human 3D genome architecture reveals chromatin topology for transcription. Cell, 2015, 163(7): 1611-1627.
20: Li, Guoliang#; Ruan, Xiaoan#; Auerbach, Raymond K#; Sandhu, Kuljeet Singh#; Zheng, Meizhen; Wang, Ping; Poh, Huay Mei; Goh, Yufen; Lim, Joanne; Zhang, Jingyao; Sim, Hui Shan; Peh, Su Qin; Mulawadi, Fabianus Hendriyan; Ong, Chin Thing; Orlov, Yuriy L; Hong, Shuzhen; Zhang, Zhizhuo; Landt, Steve; Raha, Debasish; Euskirchen, Ghia; Wei, Chia-Lin; Ge, Weihong; Wang, Huaien; Davis, Carrie; Fisher-Aylor, Katherine I; Mortazavi, Ali; Gerstein, Mark; Gingeras, Thomas; Wold, Barbara; Sun, Yi; Fullwood, Melissa J; Cheung, Edwin; Liu, Edison; Sung, Wing-Kin; Snyder, Michael*; Ruan, Yijun*. Extensive promoter-centered chromatin interactions provide a topological basis for transcription regulation. Cell, 2012, 148(1): 84-98.
21: ENCODE Project Consortium. An integrated encyclopedia of DNA elements in the human genome. Nature, 2012, 489(7414): 57. Zheng, Meizhen is a member of the ENCODE Project Consortium
22: Zeng, Huilan*; Han, Xinai; Gu, Chen; Jiang, Jianwei; Zheng, Meizhen; Yan, Yuxia; Zeng, Yaoying; Di, Jingfang. Delivery and immunologic efficacy of CpG ODN targeting B lymphocytes of umbilical cord blood by CD40 ligand-receptor-mediated carrier. Chinese Journal of Tissue Engineering Research, 2009: 974-978.
23: Zeng, Huilan*; Zhu, Kanger; Jiang, Jianwei; Gu, Huaimin; Cai, Jiye; Cheng, Longqiu; Yang, Zhigang; Zheng, Meizhen. The prevention of acute graft versus host disease by Rhodamine 123-mediated photodynamic therapy. Chinese Journal of Pathophysiology, 2000.
24: Jiang, Jianwei*; Zheng, Meizhen; Zeng, Huilan; Zeng, Yaoying; Di, Jingfang; Yan, Yuxia; Wu, Meiyu. Preparation of CD40L-PLL-CpG ODN conjugated complex and its targeting B lymphocytes. Chinese Journal of Pathophysiology, 2005.
專利：
1.Multiplex Chromatin Interaction Analysis with Single Molecule Precision. Meizhen ZHENG, Yijun Ruan, Simon Zhongyuan Tian, Chia-Lin Wei. US Patent Application number 16233860.
2. Compositions for RNA-chromatin interaction analysis and uses thereof. Yijun Ruan, Meizhen ZHENG, Junhong Oscar LUO. US Patent 9938565.
3. RNA介導(dǎo)的染質(zhì)構(gòu)捕獲方法。鄭梅珍，田忠原。中國(guó) 202210182253.X
4. 一種單分子染色質(zhì)微結(jié)構(gòu)的展示方法。田忠原，鄭梅珍。中國(guó)202210403899.6